The executive producers for the sixteenth production season are Seth MacFarlane, Richard Appel, Alec Sulkin, Steve Callaghan, Danny Smith, and Kara Vallow.

The season features guest appearances from Bill Maher, Sir Ian McKellen, Kristen Bell, Louis C.K., and Modern Family cast members Ty Burrell, Julie Bowen, and Sofía Vergara.

Freeform and FXX began exclusively broadcasting the first fifteen seasons starting in September 2021 when Family Guy officially went off Adult Swim and TBS.

When Stewie gets sent to see his school's child psychologist Dr. Cecil Pritchfield for a surprising session, he reveals major secrets about himself that would make him more normal, which includes his fake English accent.

He soon realizes that his secrets might come out, and decides not to help Dr. Pritchfield when he suffers a heart attack, choosing not to bring him his medication and letting him die, although he feels haunted by his decision as he falls asleep that night.