It is a sequel to Vacation Friends and stars Lil Rel Howery, John Cena, Yvonne Orji, Meredith Hagner, Steve Buscemi, Ronny Chieng, and Jamie Hector.

The event is interrupted by the unexpected arrival of Kyla's father Reese, who has just been released from San Quentin State Prison.

At the hotel casino, Marcus forces Ron to play a drinking game, putting Kim Wae executive Minjin in the hospital.

After reaching the hotel, Reese, Marcus, and Ron are held up by Warren's men, but are saved by Maurillio, who impersonates notorious drug kingpin Chencho Novar to negotiate a peace.

The group celebrates, but the FBI arrives, revealing that Reese was not paroled, but in fact broke out of prison to spend time with Kyla.

In April 2023, Deadline reported that a sequel to Vacation Friends was set to be released by Hulu, with the main cast returning.

[4] Whip Media, which tracks viewership data for the more than 25 million worldwide users of its TV Time app, calculated that Vacation Friends 2 was the third most-streamed film in the U.S. during the week of August 27, 2023.

[7] Nielsen Media Research, which records streaming viewership on U.S. television screens, reported that Vacation Friends 2 was watched for 246 million minutes during the week of August 21–27, 2023.

[10] Metacritic, which uses a weighted average, assigned the film a score of 38 out of 100, based on nine critics, indicating "generally unfavorable" reviews.