[6] A phytochemical study of V. rigidula[7] by workers at the Texas A & M University Agricultural Research and Extension Center at Uvalde, TX, reported the presence of over forty alkaloids, including low amounts (up to around 15 ppm) of several phenolic amines that had previously been found by the same research group in the related species Senegalia berlandieri,[8] but which otherwise are known only as products of laboratory synthesis.

Compounds found in the highest concentrations (ranging from a few hundred to a few thousand ppm) were phenethylamine, tryptamine, tyramine, and β-Methylphenethylamine (that it can be misidentified as amphetamine).

The presence of such an unprecedented chemical range of psychoactive compounds, including ones not previously found in nature, in a single plant species has led to the suggestion that some of these findings may have resulted from cross-contamination or were possibly artifacts of the analytical technique.

[10] Vachellia rigidula is used in weight loss dietary supplements because of the presence of chemical compounds claimed to stimulate beta-receptors to increase lipolysis and metabolic rate and decrease appetite.

[5] In 2015, 52% of supplements labeled as containing Acacia rigidula were found to be adulterated with synthetic BMPEA, an amphetamine isomer.