Talich's career with the Czech Philharmonic began on 30 October 1918 when he conducted the premiere of the symphonic poem Zrání (Ripening) by Josef Suk.
From 1919 to 1941 he was the orchestra's chief conductor, raising its prestige to world levels, touring widely with it, and recording Czech music for EMI.
He was also allowed to resume his association with the Czech Philharmonic, giving his last public performance with it in November 1954, though he made recordings and broadcasts with it until 1956.
Particularly noted for his interpretations of Czech composers such as Antonín Dvořák, Bedřich Smetana and Josef Suk, Talich also did much to bring the operas of Leoš Janáček into the standard repertoire.
Talich also taught a good deal, with Karel Ančerl, Jaroslav Krombholc, Charles Mackerras, Ladislav Slovák, Ivan Romanoff, and Milan Munclinger among his pupils.