[3][4][5] He has conducted studies on whether organisms can acquire cellular damage from their food;[6] the role selenium plays as a micro-nutrient with significant health benefits;[7] In 2013 he won the NIH Pioneer Award.
By studying long-lived organisms, such as naked mole-rats and microbats, and analyzing large datasets across mammals or yeast isolates, his team aims to identify "longevity signatures."
In his pursuit of understanding lifespan extension, Gladyshev has examined interventions known to prolong life in mice, discovering shared metabolic remodeling processes across various strategies.
Using longevity signatures, his team screens for new dietary, pharmacological, and genetic strategies that promise to increase lifespan, incorporating omics approaches and physiological assays to assess their efficacy.
By challenging the field to confront these essential questions head-on, he paves the way for more coherent and targeted research efforts, potentially unlocking new pathways for intervention and a deeper understanding of the aging process.
The zygote to ground zero transition is thought to be a rejuvenating phase, where the biological age is decreased, telomeres are elongated, and molecular damage is effectively cleared.
Gladyshev introduced the concept of the "deleteriome," proposing it as a fundamental characteristic defining aging by representing molecular damage and other metabolic byproducts.
In addition to his aging research, Gladyshev is renowned for his discovery of the full set of 25 human selenoprotein genes, exploring the biological roles of selenium in organisms.