[citation needed] Cruz appeared in the film Cellular and played Grace Santiago, a main character in Nip/Tuck, but she left the show just after the first season.

In 2007, she appeared as Connie Murphy, a tough Chicago police detective, in SciFi Channel's adaptation of The Dresden Files.

[citation needed] Cruz played Maria Nolan on the CW's Hidden Palms.

[citation needed] In 2009, she appeared in the horror film The Devil's Tomb and the HBO series True Blood, in which she played the part of Isabel.

In 2011 she had a recurring role as a Homeland Security agent in the Syfy series Alphas.