Valerylfentanyl is an opioid analgesic that is an analog of fentanyl and has been sold online as a designer drug.

[2] In one study, it fully substituted for oxycodone and produced antinociception and oxycodone-like discriminative stimulus effects comparable in potency to morphine in mice,[3] but failed to stimulate locomotor activity in mice at doses up to 100 mg/kg.

Fentanyl analogs have killed hundreds of people throughout Europe and the former Soviet republics since the most recent resurgence in use began in Estonia in the early 2000s, and novel derivatives continue to appear.

[5] A new wave of fentanyl analogues and associated deaths began in around 2014 in the US, and have continued to grow in prevalence; especially since 2016 these drugs have been responsible for hundreds of overdose deaths every week.

[6] Valerylfentanyl is a Schedule I controlled drug in the USA since 1 February 2018.