The Hauntley family have to learn to do things the "Pennsylvania way", especially when Vee is at school, all while keeping their monster lives a secret from humans so they don't scare them.

Of the first season's 15 episodes, 10 premiered within the month of October to tie into Halloween and were also placed on Disney Junior's streaming and video on demand venues.

[23] Emily Ashby of Common Sense Media gave Vampirina a grade of four out of five stars, praised the presence of positive messages and role models, citing friendship and honesty, writing that "vivacious vampire girl's adventures promote tolerance".

[25] Dave Trumbore of Collider included Vampirina in their "Best Animated Series Debuts of 2017" list, saying that the show is "a super-cute take on The Munsters or The Addams Family with a bit of the "new kid in school" thrown in for good measure".

[26] Charles Curtis of USA Today ranked Vampirina 5th in their "20 Best Shows For Kids Right Now (March 2020)" list, calling it a "delight with some great celebrity voices".