[2] He and his clinical collaborators pioneered the use of targeted next-generation sequencing of these proteins to identify the Mendelian genetic basis of a very large number of mitochondrial disorders.
His team used "integrative genomics" to identify all of the molecular components of the mitochondrial calcium uniporter, a key channel of communication between the organelle and the rest of the cell.
As a postdoctoral fellow he developed Gene Set Enrichment Analysis, an algorithm that is widely used in genomics and has been implemented into a popular software tool.
[citation needed] As a high school student he won first place in the mathematics category of the International Science and Engineering Fair.
He completed his internship and residency in internal medicine at Brigham and Women's Hospital in Boston, and then pursued postdoctoral training with Eric Lander at the Whitehead Institute/MIT Center for Genome Research.