The Van Antwerp Building is a high-rise in the U.S. city of Mobile, Alabama.

It is regarded as the first reinforced concrete skyscraper in Alabama and the Southeastern United States.

The building, an example of Beaux-Arts architecture, was designed by architect George Bigelow Rogers for Garet Van Antwerp, a wealthy Mobile druggist.

The tower was built to house his pharmacy store, with other offices on the upper floors.

It was completely restored and enlarged from 2014 through 2016, including historical restoration of the terracotta exterior, reinstalling the decorative cornice (removed in the 1950s), new windows, structural repairs, first floor historical renovation, and new MEP systems.