He played college football at Ole Miss and Florida and was selected by the Los Angeles Rams in the second round of the 2020 NFL draft.

[3] However, he de-committed in January of his senior year and flipped his commitment to Ole Miss, choosing the Rebels over offers from Georgia, Michigan, Oklahoma, and Tennessee.

[7] Following the 2017 season, Jefferson announced his intent to transfer from Ole Miss after the program was sanctioned by the NCAA, ultimately choosing to continue his collegiate career at Florida.

[8] Jefferson was granted immediate eligibility to play for Florida after transferring after receiving waivers from the NCAA and the Southeastern Conference (SEC).

[15] The Rams previously traded wide receiver Brandin Cooks to the Houston Texans to acquire the pick.

[18] In 2021, Jefferson saw an increase in production playing under new Rams quarterback Matthew Stafford and in light of a season-ending injury to teammate Robert Woods.

[23] On December 8, 2022, Jefferson caught the game winning touchdown pass from newly signed quarterback Baker Mayfield to beat the Las Vegas Raiders.