The station is within walking distance of Robson Square (home of the Vancouver Art Gallery, the Provincial Court of British Columbia, and a UBC satellite campus), the Orpheum Theatre, Vancouver Library Square, TD Tower, Scotia Tower and the HSBC Canada Building.

[2] In 2018, TransLink announced that Vancouver City Centre station, as well as two other Canada Line stations located in downtown Vancouver, would receive an accessibility upgrade which includes additional escalators.

[3] Construction is expected to begin in early 2019 with completion by the fourth quarter of 2019.

Passengers are able to reach Granville station (on the Expo Line) during regular retail hours while remaining indoors by walking through Pacific Centre or Vancouver Centre and Hudson's Bay department store, although the only direct transfer point between the Canada Line and the Expo Line is at Waterfront station.

The following bus routes can be found in close proximity to Vancouver City Centre station:[7]