She has also appeared in a number of films, including Spider-Man 2 (2004), Shadowboxer (2005), Man of the House (2005), Gridiron Gang (2006), Death Proof (2007), Nothing like the Holidays (2008), Madea Goes to Jail (2009), Julie & Julia (2009), Wall Street: Money Never Sleeps (2010), and Stand Up Guys (2012).

In 2003, Ferlito starred as Lizette Sanchez in John Leguizamo's boxing drama Undefeated,[7] which earned her an NAACP nomination for Outstanding Actress in a TV movie.

"[9] Ferlito was a series regular on the first two seasons (2004–2005) of CBS's CSI: NY, as Aiden Burn, a member of the forensic investigation team led by Gary Sinise.

[13] After CSI: NY, Ferlito starred in several films, among them Wall Street: Money Never Sleeps;[14] Nora Ephron's Julie & Julia opposite Meryl Streep, Stanley Tucci and Amy Adams; Tyler Perry's Madea Goes to Jail;[15] and Alfredo De Villa's Nothing like the Holidays (originally titled Humboldt Park) with Alfred Molina, John Leguizamo and Jay Hernandez.

[citation needed] She also appeared in Lee Daniel's Shadowboxer with Helen Mirren and Cuba Gooding Jr.[20] In 2012, Ferlito was cast in the feature film, Stand Up Guys, opposite Al Pacino, Christopher Walken and Alan Arkin.