Although born in Videira, Santa Catarina, Grazziotin based her political career in the state of Amazonas.

She is the third Communist Senator ever in the history of Brazil, after Luís Carlos Prestes and Inácio Arruda.

On 1985, Vanessa Grazziotin graduated in the Pharmacy College of the Federal University of Amazonas.

[2] Through PC do B, she was a councilwoman for Manaus for nine straight years, from 1989 to 1998, when she successfully ran for a seat in the Chamber of Deputies.

[2] Among her proposals in the Chamber were the creation of a Green Seal for goods manufactured on the Manaus Free Trade Zone, the prohibition of the distribution of plastic bags, and the creation of the Day of African and Amerindian Culture (to be celebrated on May 13).

[4] Her election was rather impressive, once she defeated Arthur Virgílio, a prominent Senator from the Brazilian Social Democratic Party (PSDB).

Virgílio accused Grazziotin of buying votes, the reason why he was called a "bad loser" by newsmagazine Istoé.

[5] On May 2, 2016, the Regional Electoral State Attorney presented a motion to the Superior Electoral Court in order to abrogate her Senate mandate for crimes against the Election Law regulations (money abuse during campaign).

Grazziotin is married to fellow Communist politician Eron Bezerra, who acted as State Secretary for Rural Production in the Eduardo Braga administration and was recently elected to the Chamber of Deputies through PC do B.