Varney Air Lines was an American airline company that started service on April 6, 1926, as an airmail carrier.

Pilot Leon D. Cuddeback flew the first eastbound CAM-5 flight, leaving in the early dawn hours from Pasco.

[citation needed] Varney added a Breese-Wilde Model 5[3] and replaced its original Swallows with Stearman C3s and thereafter upgraded as new equipment became available.

Following cancellation of all domestic airmail contracts by the Roosevelt administration in 1934, Robert F. Six learned of an opportunity to buy into the Southwest Division of Varney Speed Lines which needed money to handle its newly acquired Pueblo-El Paso route.

Six was introduced to Louis Mueller, who had helped found the Southwest Division of Varney in 1934, and bought into the airline with US$90,000 becoming general manager on July 5, 1936.