Varnville is a town in Hampton County, South Carolina, United States.

Varnville grew as a result of its close proximity to the county seat as well as its connections with surrounding agricultural areas.

In 1993, several scenes from the film Forrest Gump were shot in Varnville, of which some were used to create the fictional town of Greenbow, Alabama.

South Carolina Highway 63 leads east from Varnville 27 miles (43 km) to Walterboro.

According to the United States Census Bureau, Varnville has a total area of 3.8 square miles (9.9 km2), all land.

Patrick Henry Academy, located four miles west of Varnville, is the main private school in Hampton County.

Varnville also is home to a branch of the Technical College of the Lowcountry for higher education.