Hosted by Vasili Kanidiadis, each episode of the show, which is unscripted, focuses on the plants and produce from home gardens in Melbourne and surrounding areas, with emphasis on traditional and organic methods of gardening and healthy eating.

In 2007, after two years of negotiations, the show moved to SBS, collaboratively produced by I Like It Productions (a partnership between Maresi Productions and Renegade Films), with the main appeal being the reach of a national audience, unavailable up to that point on Channel 31.

The format remained largely unchanged, owing to Vasili's insistence that the show retain its 'home video' feel.

Vasili sees this as an important aspect of the show, saying that he wants to make "people feel like they are watching their next-door neighbour's house or their aunty or uncle's house.

Vasili's Garden has been broadcast on 7TWO since 2016 growing to a one hour episode.