Made countless discoveries in organic and inorganic chemistry, was the first one to propose to make a network of weather station spanning the whole country.

The Karazins originated from the noble family of Karadzhi or Karadžić, whose representatives migrated to Russia during the reign of Peter the Great.

His father was Nazary Aleksandrovich Karazin, a Russian Imperial Army officer noted for his involvement in Pârvu Cantacuzino's 1769 rebellion in Wallachia.

When Alexander I took power, Karazin began petitioning him with his views on government development, pointing out the state's need to invest in education.

[2] On 17 January 1805, the Imperial Kharkov University was inaugurated, but Karazin did not take part in the opening ceremony, as by that time he had lost his position with the Ministry of Education.

Karazin repeatedly voiced criticism of what he viewed as Alexander's resistance to self-government and national education in the Russian Empire.