Vasily Afanasyevich Khomenko (30 March 1899 – 9 November 1943) was a Soviet army commander, and lieutenant general.

Vasily Afanasyevich Khomenko was born on March 30, 1899, in a Ukrainian family in the village of Petrovsky, now in the Borisoglebsky District, Voronezh Oblast.

Under his leadership, the army participated in the Battles of the Caucasus, Rostov, Miusskaya, Donbass, Melitopol offensive operations and liberated the cities of Voroshilovsk (now Stavropol), Taganrog, Yudanov (now Mariupol) and Azov.

At the end of October 1943, the army was withdrawn to the front reserve and occupied the defense of the line Zavadivka - Kakhovka - Dniprjany.

Joseph Stalin mistakenly believed he had defected to Nazi Germany and disbanded his army.