Phase contrast magnetic resonance imaging (PC-MRI) is a specific type of magnetic resonance imaging used primarily to determine flow velocities.
PC-MRI can be considered a method of Magnetic Resonance Velocimetry.
Since modern PC-MRI is typically time-resolved, it provides a means of 4D imaging (three spatial dimensions plus time).
[2] Atoms with an odd number of protons or neutrons have a randomly aligned angular spin momentum.
When placed in a strong magnetic field, some of these spins align with the axis of the external field, which causes a net 'longitudinal' magnetization.
Then, energy is added to the system through a Radio frequency (RF) pulse to 'excite' the spins, changing the axis that the spins precess about.
Different tissues respond to the added energy in different ways, and imaging parameters can be adjusted to highlight desired tissues.
All of these spins have a phase that is dependent on the atom's velocity.
of a spin is a function of the gradient field
If we only consider static spins and spins in the x-direction, we can rewrite equation for phase shift as: We then assume that acceleration and higher order terms are negligible to simplify the expression for phase to: where
[3] [4] The phase shift is measured and converted to a velocity according to the following equation: where
will be incorrectly calculated as moving in the opposite direction.
is the signal-to-noise ratio of the image (which depends on the magnetic field of the scanner, the voxel volume, and the acquisition time of the scan).
(above the maximum velocity expected in the scan) will allow for the proper velocity quantification, but the larger dynamic range will obscure the smaller velocity features as well as decrease SNR.
will be application dependent and care must be exercised in the selection.
In order to further allow for proper velocity quantification, especially in clinical applications where the velocity dynamic range of flow is high (e.g. blood flow velocities in vessels across the thoracoabdominal cavity), a dual-echo PC-MRI (DEPC) method with dual velocity encoding in the same repetition time has been developed.
[5] The DEPC method does not only allow for proper velocity quantification, but also reduces the total acquisition time (especially when applied to 4D flow imaging) compared to a single-echo single-
[6] When each dimension of velocity is calculated based on acquisitions from oppositely applied gradients, this is known as a six-point method.
[7] Then, the velocities can be solved based on the phase information from the corresponding phase encodes as follows: The balanced four-point method also includes four sets of encoding gradients.
The first is the same as in the simple four-point method with negative gradients applied in all directions.
[8] This gives us the following system of equations: Then, the velocities can be calculated: For medical imaging, in order to get highly resolved scans in 3D space and time without motion artifacts from the heart or lungs, retrospective cardiac gating and respiratory compensation are employed.
Beginning with cardiac gating, the patient's ECG signal is recorded throughout the imaging process.
Similarly, the patient's respiratory patterns can be tracked throughout the scan.
After the scan, the continuously collected data in k-space (temporary image space) can be assigned accordingly to match-up with the timing of the heart beat and lung motion of the patient.
This means that these scans are cardiac-averaged so the measured blood velocities are an average over multiple cardiac cycles.
[9] Phase contrast MRI is one of the main techniques for magnetic resonance angiography (MRA).
This is used to generate images of arteries (and less commonly veins) in order to evaluate them for stenosis (abnormal narrowing), occlusions, aneurysms (vessel wall dilatations, at risk of rupture) or other abnormalities.
MRA is often used to evaluate the arteries of the neck and brain, the thoracic and abdominal aorta, the renal arteries, and the legs (the latter exam is often referred to as a "run-off").
In particular, a few limitations of PC-MRI are of importance for the measured velocities:
A Vastly undersampled Isotropic Projection Reconstruction (VIPR) is a radially acquired MRI sequence which results in high-resolution MRA with significantly reduced scan times, and without the need for breath-holding.