[13] At the 2007 World Championships in Chicago, he won silver by beating Abner Cotto in the first round, Theodoros Papazov, Mikhail Bernadski, Arturo Santos Reyes, and Li Yang in the semifinal to reach fellow southpaw and Russian favorite Albert Selimov, to whom he lost 11–16.

[14] He defeated Han Soon-Chul of South Korea in the final, 19–9, and was a strong candidate to win the Val Barker Trophy for a second time in what would have historically been an unprecedented feat.

[16][17] In November 2017, boxing website The Sweet Science conducted a readers' poll, which ran for several weeks, to determine the amateur boxer regarded by the public majority as the all-time best.

Alongside Lomachenko, the five other standout finalists selected were: László Papp, Teófilo Stevenson, Félix Savón, Mark Breland, and Guillermo Rigondeaux.

Lomachenko made his professional debut in United States on 12 October 2013 as part of the undercard to Timothy Bradley vs. Juan Manuel Márquez, defeating Mexican fighter José Ramirez with a fourth-round knockout.

Lomachenko, for his part, stated he felt the decision was fair and accepted blame for not following through with his corner's game plan, promising to learn from the experience and come back stronger.

[25][26] The referee of the fight, Laurence Cole, was roundly criticized by many boxing media outlets for his seemingly ignoring the very many foul blows by Salido, and his perceived failure to properly conduct the match.

This fight took place on the undercard of Manny Pacquiao vs. Chris Algieri on HBO PPV bout on November 22, 2014, at the Cotai Arena, Venetian Resort in Macao.

Although Piriyapinyo's record of 52 wins and 1 loss made the fight sound challenging for Lomachenko, the only time he stepped up in his 11-year career was in 2012 against Chris John, which he lost via unanimous decision.

In front of a sell-out crowd of 2,828, mostly Ukrainian, Lomachenko successfully retained his WBO title for a second time after Sosa failed to return for round 10 when his trainer pulled him out.

Lomachenko said he wanted to follow this victory by only fighting current world champions at super featherweight for a chance to unify the division or he would move up lightweight.

A fight with the two-weight world champion and reigning super bantamweight title holder, a two-time Olympic Gold Medalist and one of the most successful amateur boxers ever, would take place at 130 pounds.

[84] In front of a sell-out crowd of 5,102 at the Theater, Lomachenko retained his WBO title, dominating the fight with superior boxing skills, forcing Rigondeaux to retire on his stool after round 6.

Arum stated he was unable to make unification fights at super featherweight against WBC champion Miguel Berchelt and WBA titleholder Alberto Machado which was the main reason for the move up.

In doing so he became the fastest fighter ever to win titles in 3 different weight classes (only 12 professional fights) shattering the previous record of 20 held by Jeff Fenech.

[108] After winning the WBA (Super) and The Ring lightweight titles, promoter Arum stated that Lomachenko would defend the belts on 25 August 2018 at The Forum in Inglewood, California.

In the interview, he also stated it would likely be a unification fight against the winner of the Raymundo Beltran vs. José Pedraza bout, which was scheduled to be contested on 25 August.

[116] In September, The Ring magazine announced the unification fight between Lomachenko and Pedraza would take place on 8 December 2018 at the Hulu Theatre in New York City.

Top Rank intended to finalize the deal with promoter Lou DiBella, which would see Commey vs. Chaniev take place on 2 February 2019 at the Ford Center in Frisco, Texas.

[126] On 20 February, it was announced that Lomachenko would defend his WBA (Super), WBO and The Ring titles against Crolla at the Staples Center in Los Angeles on 12 April 2019.

[135] Lomachenko faced fellow 2012 Olympic gold medallist Luke Campbell on 31 August 2019, at The O2 Arena in London in front of a sold-out crowd of over 18,000.

[137] In his in-ring interview, Lomachenko called for a lightweight unification fight with the winner of Richard Commey vs. Teófimo López, who contested for the IBF title in December.

[137][138] In September 2020, Lomachenko agreed to fight newly crowned undefeated IBF lightweight champion, Teófimo López, on 17 October 2020 at the MGM Grand Conference Center in Paradise, Nevada.

"[149] In an attempt to put his name back into contention for a shot at his old titles, Lomachenko agreed to face former IBF lightweight champion, Richard Commey, on 11 December 2021 in New York.

When asked about fighting newly crowned unified lightweight champion, George Kambosos Jr., who had upset Teofimo Lopez a few weeks previously, Lomachenko jumped at the idea, stating that he 'needs this chance' and would be willing to fly to Australia if necessary.

[156][157][158][159] Ultimately, Lomachenko suffered his third professional defeat, losing via unanimous decision with scores of 116–112, 115–113 and 115–113, all in favor of the champion Haney who retained his world titles.

[160] However, the decision was greatly disputed, as many onlookers felt Lomachenko had done enough to win, including fellow boxers Shakur Stevenson and Jorge Linares, who had previously predicted a Haney victory.

[168][169] Following Lomachenko's victory over Kambosos, discussions for a unification bout against undefeated WBA lightweight champion Gervonta Davis commenced, with both sides initially showing interest.

[177] Lomachenko was in Greece when the invasion began (on 24 February 2022), and his flight home to Ukraine the next day was delayed due to air traffic being grounded.

[177] Lomachenko is known for his exceptional footwork, head movement, speed, ability to switch stances, and skill at throwing punches at uncanny angles.