Its service area is primarily Vaughan, King, and Richmond Hill in the southwestern and south-central portions of York Region.

[1] The 11-storey hospital[3] is situated on a 25-hectare property on the northwest corner of Jane Street and Major Mackenzie Drive, adjacent to Canada's Wonderland.

[5] The VHCF was required to raise about $200 million to fund the city's share of the projected $1.3 billion construction costs and for acquisition of equipment.

[5] Michael DeGasperis later became chairman of the board, and in November 2007 he and others established the privately owned Vaughan Health Campus of Care (VHCC).

[5] A 2008 report by Deloitte Consulting commissioned by the Central LHIN stated that the proposed hospital should be located on the Highway 400 corridor.

[8] In 2009, VHCC negotiated a deal with Cedar Fair to acquire the northern portion of land on the Canada's Wonderland campus.

[10] On 16 March 2011, Minister of State in the federal cabinet Gary Goodyear announced that VHCC had been awarded a $10 million grant from the Economic Development Agency.

[12] Greg Sorbara stated that this was a "reward for getting Julian Fantino elected" in the November 2010 by-election for the federal electoral district of Vaughan.

[12] DeGasperis and Sam Ciccolini, members of the VHCC board of directors, were fundraising co-chairs for Fantino's election campaign.

[12] The grant was also criticized for the perceived impropriety of the federal government funding projects of provincial jurisdiction (health care).

[5] In a September 2013 letter to the city of Vaughan, DeGasperis stated that VHCC could claim damages if more than 40 acres of the land was allocated for the hospital.

The land acquired from Canada's Wonderland were purchased via an $80 million debenture from the city of Vaughan,[4][17] which implemented a property tax surcharge in 2009 to recoup the costs.

[18][20] About 90 percent of the construction costs was borne by the Government of Ontario, and the remainder was funded from donations from private sources, including residents and businesses.

[38] It was built on the grade separated eastern underpass connecting the hospital lands to Canada's Wonderland, and is a dedicated accessible pedestrian and cycling walkway.

[41] The hospital is expected to handle 140,000 medical imaging exams, 6,300 surgeries, 3,100 births, and 1,800 urgent care pediatric visits annually.

[47] The managed services contract includes "procurement, installation, systems integration, maintenance and timely updates".

[49] In 2024 the Province of Ontario announced the funding for the creation of a School of Medicine with York University[50] and will be located next to the hospital.