[1] Soviet engineers flooded the lower part of the river to form the Vazuza Reservoir.

The main tributaries of the Vazuza are the Kasnya, the Gzhat (both right), the Losmina and the Osuga (left).

The river flows north, crosses into Sychyovsky District, and downstream of the town of Sychyovka turns east.

Downstream of the mouth of the Gzhat it makes a short stretch of the border between Tver and Smolensk Oblasts, flowing northwest, and further downstream turns northeast and deviates from the border into Tver Oblast.

The towns of Zubtsov, Sychyovka, and Gagarin, as well as the selo of Novodugino, the administrative center of Novoduginsky District, are all located in the drainage basin of the Vazuza.