Velký Osek is a municipality and village in Kolín District in the Central Bohemian Region of the Czech Republic.

The word osek or osečený kmen denotes a trimmed trunk.

The first written mention of Velký Osek is from 1228, when it was owned by the St. George's Convent in Prague.

[6] The main landmark of Velký Osek is the Church of the Sacred Heart of Jesus.

It has an Art Nouveau interior, which comes from the abolished Church of Saint Wenceslaus in Prague-Bohnice.