The Metro station connects to Exo's commuter rail network by a pedestrian tunnel, permitting access to platforms providing service on the Vaudreuil-Hudson, Saint-Jérôme and Candiac lines.

However, opposition from Westmount residents as well as instability in the underlying rock formation forced their consolidation into one station, with the result that the tunnel between Vendôme and Place-Saint-Henri is the longest on the Island of Montreal.

It contains a plaque commemorating Jean Descaris, a 17th-century pioneer, and his descendant Alphonse Décarie, on whose land Vendôme and Villa-Maria Metro stations were built.

[5] A short tunnel under the railway tracks links this Metro station to the McGill University Health Centre, which opened in 2015.

In fall 2017, construction began on another entrance to the station, located east of the bus loop.

This was designed to offer a wheelchair-accessible direct connection between the metro station, the commuter train platforms, and the hospital via a pedestrian tunnel.

The first artwork is by Quebec artist Marcelle Ferron, and consists of a stained-glass window and a stainless steel sculpture over the tracks.