He was a leading authority on commercial law, and after the Communist coup d'état on 9 September 1944 was one of the regents of underage tsar Simeon II.

In 1919 he was the Minister of Justice in Teodor Teodorov's second cabinet, and took part in the Bulgarian delegation for peace negotiations in Paris (before the Treaty of Neuilly).

During World War II he participated as an independent member in the Fatherland Front and entered its leadership.

[1] From 1945, Venelin Ganev opposed the increasing influence of the Bulgarian Communist Party and joined the opposition.

In 1947 he was dismissed from his position at the University of Sofia and interned in Dryanovo (until 1956), and in 1948 he was expelled from the Bulgarian Academy of Sciences.