It is located within the mainland frazione of Mestre, and is classified by its owner, Rete Ferroviaria Italiana, as a gold category station.

Both stations are managed by Grandi Stazioni, and they are linked with each other by the Ponte della Libertà (English: Liberty Bridge) between the mainland and the island.

In that case, passengers directed to/coming from the Historical Center of Venice they should use the 24/7 ACTV bus service (lines 2 and H1) from Piazzale Roma to Venezia Mestre station and vice versa.

The following services call at the station: Venezia Mestre is a crucial part of the railway system of the north east of Italy.

The new line from the former Orgnano double junction over the Maerne viaduct to Venezia Mestre was officially opened on 30 May 2008 and entered service on 10 June 2008.

The Venezia Mestre station building is also being modified with a view to better organization of spaces, and to suit commercial services closely linked to the railway, such as the ticket office.