On December 27, 1945, the owners of Cervecería Caracas (Caracas Brewery), Sabios de Vargas (Vargas Wisemen), Navegantes del Magallanes (Magellan Navigators), and Patriotas de Venezuela (Venezuelan Patriots) created the Venezuelan Professional Baseball League.

Sabios de Vargas, led by Daniel 'Chino' Canónico, became the first champion, with a record of 18 wins and 12 losses.

On August 8, 1952, Pablo Morales and Oscar Prieto Ortiz purchased the Cervecería Caracas team from Martín Tovar Lange, as the Caracas Brewery Co. was unable to continue sponsoring the team and it had the highest payroll of the league.

On October 17, 1952, the 1952-1953 season of the league started, with the first game of Leones del Caracas vs. Venezuela BBC.

The next season, alongside the start of limited television coverage of the league, would see the departure of the teams Sabios de Vargas and Venezuela BBC due to economic problems, being replaced by two teams (Gavilanes and Pastora) from the professional league of the Zulia State, from western Venezuela.

The 1956-1957 tournament would see further changes: the Navegantes del Magallanes team was purchased by advertisers Joe Novas and Joe Cruz and renamed as Oriente, leaving the league made of Leones del Caracas, Oriente, Pampero and Industriales de Valencia.

For the 1968-1969 tournament, the Industrymen left the city of Valencia and relocated to Acarigua with a new name: Los Llaneros.

The 1970s saw the first successes for Venezuelan teams outside of Venezuela since the amateur championships of the 1940s, with the Navegantes del Magallanes winning two Caribbean Series.

The 1980s saw the Leones del Caracas winning five tournaments, consolidating their lead as the most successful team in the league.

Leones del Caracas also went on to win three championships in a row starting in the 1979–80 season, and their first Caribbean Series in 1982.

In recent years, Tigres de Aragua has become the most dominant team of the league, winning the crown seven times in the last fifteen years, including three times in a row from the 2006-07 season to the 2008-09 season and also winning the Caribbean Series in 2009.

[2] This ban was later limited to only Navegantes del Magallanes and Tigres de Aragua,[3] and has since been lifted for all clubs.