Further east, it briefly forms the boundary between Palms and Culver City and passes near Sony Pictures Studios.

Continuing northeast into the Crestview neighborhood in West Los Angeles, the SR 187 designation terminates at the intersection with Cadillac Avenue and the ramp carrying traffic from westbound I-10.

[1] Continuing to parallel Washington Boulevard directly to its south, as it does for much of its length, the route proceeds between the Picfair Village neighborhood in West Los Angeles and Lafayette Square in Mid-City, through the Mid-Wilshire district, through Arlington Heights and Harvard Heights, dips under the Harbor Freeway, and continues into the heart of downtown Los Angeles, where it turns into East 16th Street at Main Street.

An extra rail was installed in 1905, which created a dual-gauge streetcar thoroughfare which was shared with the Los Angeles Railway.

In that year part of the Pacific Electric right of way was taken and Venice Boulevard was cut through from La Brea Avenue to Crenshaw.