Zoë Carter has severe depression and is sent to therapy after telling her parents about transitioning to a teenage girl, leading to problems in Punxsutawney, Pennsylvania, with the family relocating to the fictional town of Salem, to begin anew.
[8] She also wrote that the first weeks of the comic were not meant to have any character development or part of a storyline, and noted that the shirt worn by Zoë was a "simplified symbol" for trans woman designed by Matt Nishii.
Frasier said she was inspired to begin the comic, after reading Garfield, Sluggy Freelance, and being encouraged by her roommate to put it online.
[18][19][d] In December 2015, Frasier contributed to a holiday illustration featuring Zoë alongside trans protagonists of Jessica Durling's 2punk4you (Jess & Seb), Jenn Dolari's Closetspace (Carrie & Allison), Jessica Udischas's Manic Pixie Nightmare Girls (Jesska), Sophie Labelle's Assigned Male (Stephie), and Jocelyn Samara DiDomenick's Rain (Rain).
[20] Laura Seabrook, in a review for Polare, called the comic "really important", praising Zoe as a well-rounded, believable character, accompanied by a consistent and well-done supporting cast.