[4] She worked as an elementary school teacher, and was the camp coordinator for Gender Creative Kids Canada.

[8][9][10] Labelle is the author and illustrator of Assigned Male, a webcomic and series of zines addressing issues of gender norms and privilege.

[3][6][10] Labelle said that while working with transgender children, she "noticed how negative everything we tell them about their own body is, so I wanted to create a character that could respond to all those horrible things trans kids hear all the time.

She received death threats, her home address was posted in online forums, and her web site and social media accounts were compromised (leading her to take them offline temporarily).

[16][17] In the wake of the harassment, Labelle advocated for Canadian Bill C-16 to protect gender identity and expression, and for stronger laws against cyberbullying.