[3] In Paris, Janacópulos studied violin with Romanian composer George Enescu, but stopped playing it to dedicate herself to singing.

The soprano has had a successful career performing in several countries in Europe (Germany, Belgium, Netherlands, France, Spain, Italy, Switzerland), North America (United States) and South America (Argentina and Brazil) and Asia (Java, Sumatra and Celebes).

She performed works by Igor Stravinsky, Sergei Prokofiev (with whom she adapted his opera The Love for Three Oranges),[4] Darius Milhaud, Manuel de Falla and Heitor Villa-Lobos, helping to disseminate the work of the Brazilian composer abroad.

Janacópulos returned to Brazil in 1940, establishing herself in São Paulo, where she presented a classical music program for Radio Gazeta for eight years.

[8] Janacópulos' archives are collected in the Federal University of the State of Rio de Janeiro Center of Language and Arts library; an auditorium at the institution is also named after her.