VT 110 follows the valley of the First Branch White River through the Orange County towns of Tunbridge and Chelsea, which contain multiple historic buildings and covered bridges.

VT 110 heads north as a two-lane highway through the valley of the First Branch White River.

The highway passes the Royalton Mill Complex before entering the Orange County town of Tunbridge.

The highway crosses Cram Brook and passes the Moxley Covered Bridge on its way to the town center.

At Waterman Street, which leads to the historic Nichols House, VT 110 turns northeast, crosses the Jail Branch River in the village center, and reaches its northern terminus at a roundabout junction with US 302 (East Barre Road).