In Orleans, VT 58 runs concurrent to U.S. Route 5 (US 5) for a short distance, interchanging with Interstate 91 (I-91) at exit 26 during that interval.

Soon the residences give way to just woods as VT 58 reaches the Orleans County line along the ridge of Hazens Notch.

Soon crossing into the town of Lowell, the dense woods around VT 58 begin to break as it leaves Hazens Notch, passing nearby Green Hill Road.

The route continues southeast through Irasburg, doing the same southeast–northeast jog it made in Lowell, climbing a ridge and past some large farms before reaching VT 14, where it passes a small housing development.

[3] Running alongside the Black River, VT 58 passes the eastern end of Under the Hill Road, leaving the center of Irasburg.

Now winding east along the riverside, VT 58 quickly turns away from the river in Irasburg, soon reaching a junction with U.S. Route 5.

At this junction, US 5 and VT 58 become concurrent, running southeast as a divided highway as it enters a partial cloverleaf interchange with Interstate 91 (exit 26).