Originally intended to treat the criminally insane, the hospital eventually took in patients with a wide variety of problems, including mild to severe mental disabilities, epilepsy, depression, alcoholism and senility.

[citation needed] During the tenure of Dr. Eugene A. Stanley as superintendent (1918–1936), the hospital expanded – with a patient population peaking at 1,728 in the mid-1930s – and constructed a new three-story building specifically for the treatment of women.

[citation needed] In 2011, Tropical Storm Irene flooded the property 2.5 feet (0.76 m) above predicted 100-year level.

[clarification needed] Empty floor space was converted into state offices.

[5] In 2011, the hospital closed due to flooding in the aftermath of Tropical Storm Irene in Vermont.