[1] Early in her career, De la Cruz worked as an anchor and reporter at an NBC affiliate in Yuma, Arizona.
During her time at KYMA-DT, De la Cruz covered numerous stories on Mexico–United States border issues, the nation's nursing shortage, and the plight of the migrant farm worker.
[citation needed] De la Cruz hosted a music show for SonicNet/Digital Planet, where she interviewed many different artists including: Hoobastank, Vertical Horizon, Eagle-Eye Cherry and The Roots.
De la Cruz joined CNN in 2003 and in 2007, moved from the network's world headquarters in Atlanta to the New York City offices.
During the 2008 Consumer Electronics Show in Las Vegas, De la Cruz interviewed keynote speaker Bill Gates[5] of Microsoft shortly before his retirement.
She is one of the first and only cable network news journalists to shoot segments with a Flip Mino video camera, which she edits herself on a Mac.
[citation needed] De La Cruz was a host for the live stream of the first weekend of the Coachella Valley Music and Arts Festival on YouTube from April 15–17, 2022.
Nine Inch Nails front man Trent Reznor joined the cause and raised hundreds of thousands of dollars for Eric as well as bringing much needed attention to the fight for proper health insurance.
[10] Tweeple, a magazine covering news related to Twitter, named De la Cruz as one of its picks to watch,[11] calling her a "Trailblazer" and saying "...She is an inspiration and a catalyst for change beyond just Eric’s scenario.
The national exposure is generating more and more debate on the problems in Medicaid, Medicare in the United States..." On the one year anniversary of the passage of health care reform, De la Cruz made an appearance on MSNBC to share her brother's story.