[5][6][7] Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane.

It is associated with the perinuclear vesicular structures of the early endocytic compartment.

It has been found that VAMP8 interacts specifically with the soluble NSF-attachment protein (alpha-SNAP), most likely through an VAMP8-containing SNARE complex.

[7] Phosphorylation of VAMP8 inside the conserved SNARE-domain can suppress vesicle fusion.

[8] Vesicle-associated membrane protein 8 has been shown to interact with STX4,[9][10] SNAP23,[9][11] STX1A,[12] STX8[13] and STX7.