Built in the 18th century as “Strada Nuovissima” (Italian for “the most new street”), it is one of the Strade Nuove (Italian for "new streets") inscribed in July 2006 in the list of UNESCO World Heritage Site Genoa: the Strade Nuove and the system of the Palazzi dei Rolli.

[2] During the Reinassance period, the nobility of the Republic of Genoa started a careful town planning to transform the existing medieval city and initiate a sizeable urban expansion to the North.

[3] After this expansion, however, the two “Strade Nuove” - the 16th-century Strada Nuova (now via Garibaldi) and the 17th-century Strada Balbi (now via Balbi) – remained without a comparable thoroughfare connecting them, separated by a number of medieval alleys and squares.

In the 18th century, therefore, the city decided to improve the connection between the two monumental streets and give a boost to the westward traffic through the construction of Strada Nuovissima.

This required sacrificing some ancient working-class homes and adapting some of the aristocratic palaces, such as the Palazzo Lomellini Doria-Lamba, which were located alongside the new street.