The road was first mentioned as strata regia in a document issued by Margrave Henry III of Meissen in 1252, while its origins date back to the 8th and 9th centuries.
After the downfall of the Imperial power in Central Germany in favour of the Saxon House of Wettin following the 1307 Battle of Lucka, the road lost its royal status and from the 14th century this route could no longer really be spoken of as a "Via Regia".
It remained under sovereign control of e.g. the Bohemian Crown in Upper Lusatia, the Saxon electors, the Abbey of Fulda, and the Archbishopric of Mainz and was chartered through tolling.
From the west came Flemish blankets, from the east wood, pelts, wax and honey, and the middle section controlled the German indigo (Isatis tinctoria) of the Thuringian Basin as well as the mining products of the Saxon Ore Mountains.
After the final defeat of Napoleon, the significance of the road declined, since, as a result of the reduction of the Kingdom of Saxony by large parts of its Lusatian territories at the Congress of Vienna, the toll on behalf of Leipzig was no longer continued.