Vibralactones are a group of related terpenoid chemical compounds, the first of which were isolated from the Basidiomycete Boreostereum vibrans in 2006.
[1] Additional vibralactones have also been isolated from the fungus Stereum hirsutum.
[2] Vibralactone A has attracted research interest because it is an inhibitor of pancreatic lipase (IC50 0.4 μg/mL) with in vitro activity comparable to that of the obesity drug orlistat.
[1][3] Several laboratory syntheses of vibralactone A have been developed.
[3][4]