The Apostolic Vicariate of Pakse (Latin: Vicariatus Apostolicus Paksensis) is a Latin rite missionary territorial jurisdiction of the Catholic Church in Laos.

As an apostolic vicariate, it is a pre-diocesan jurisdiction, entitled to a titular bishop.

It is exempt, i.e., not part of any ecclesiastical province but directly dependent on the Holy See and notably its missionary Dicastery for Evangelization.

As of 2016, only about 15,000 (1.3%) of approximately 1.3 million people living in the area are members of the Catholic Church, half of them belonging to ethnic minorities.

There are also 19 sisters from the Soeurs de la Charite (Sisters of Charity) and the Filles Marie de la Croix (Daughters of Mary of the Cross).