The current vice-president is Jane Naana Opoku-Agyemang, who took office on 7 January 2025, under President John Mahama.

[1] The provisions of article 62 of the 1992 Constitution apply to a candidate for election as Vice-President.

The candidate must be: The president and vice president are elected on a single ticket; all presidential candidates must lodge the name of their running mate when filing for election.

He was elected president in his own right that December, and was allowed to run for reelection in 2016 since he had ascended with only six months remaining in Mills' term.

The Vice-President-elect must repeat the following: "I,(name) having been elected to the office of Vice-President of the Republic of Ghana, do (in the name of the Almighty God swear) (solemnly affirm) that I will be faithful and true to the Republic of Ghana; that I will at all times preserve, protect and defend the Constitution of the Republic of Ghana; and I dedicate myself to the service and well-being of the people of the Republic of Ghana and to do right to all manner of persons.