He then went to New York, United States and enrolled at Columbia University to study mercantile law.

[3] In 1946, Francisco was elected to the Senate of the Philippines[4] as a candidate of the Liberal Party, winning the largest number of votes.

In the Senate, he was responsible for many bills, including Act 52, which re-established the Court of Appeals.

In the 1949 elections, Francisco ran for Vice President of the Philippines as Senate President Jose Avelino's running mate but lost to Fernando Lopez with 1.73% of the vote.

Their son Ricardo Francisco served as a justice of the Supreme Court of the Philippines from 1995 to 1998.