Born in Mar del Plata, Vuoso began his career at Independiente in 2000, then transferring to English club Manchester City in 2002, where he did not play in a single league match.

Vuoso chose to represent Mexico at international level, making his debut in 2008 and featured for them at the 2015 Copa América.

Despite moving from the Premier League to the Primera Division Mexicana, in the beginning of his stay in Mexico, Vuoso experienced the same problems at Santos Laguna that he faced at Manchester City.

Coming to a club that already boasted an attack that featured Chilean playmaker Rodrigo Ruiz and Mexican striker Jared Borgetti, Vuoso was exclusively played as a substitute during the first part of the Apertura 2003 season.

As fate would have it however, Vuoso was thrown into the starting mix when Borgetti suffered a minor injury that required a two-week absence from the pitch.

Newly appointed América manager Luis Fernando Tena brought Vuoso to the club as a reinforcement for the Apertura 2006 campaign.

Upon receiving his Mexican citizenship, Vuoso said that if Hugo Sánchez, former coach of the Mexico national team, ever needed a striker, he would be honored to wear the green jersey while helping the country of his new home win.

He would make world football headlines by scoring a memorable brace in what was a surprising tie against Chile whom were the eventual Copa America winners.

During his time with Manchester City, he, along with players Daniel Van Buyten and Djamel Belmadi, were the victim of a theft by two bankers.