In 1842, the Law of Confiscation of Mayorazgos that made him lose the territories of his large estates (Osorio, Moscoso, Cárdenas, Fernández de Córdoba, Guzmán, etc.

A widower in 1843, he immediately became close to Isabella II and his eldest son and heir, José María, married into the royal family in 1847 with Infanta Luisa Teresa.

[5] Isabella II appointed him, in 1854, her Caballerizo mayor and, just two years later, her Sumiller de Corps, who, as head of the Royal Chamber, implied enormous confidence from the queen.

In fact, he would not hesitate to marry his daughter Rosalía, in 1859, to José María Ruiz de Arana, a well-known lover of the queen.

After his death on 22 February 1864,[6] a testamentary commission was established to guarantee the distribution of his substantial inheritance and titles, headed by José Genaro Villanova as executor.