Part of the Mississippi Delta and the historic cotton culture, Warren County had major plantations.

This area was once along the Mississippi River, but has since become an oxbow lake and marsh and no roads traverse this strip of land.

As of the 2020 United States census, there were 44,722 people, 18,235 households, and 11,480 families residing in the county.

2005 census estimates based on the American Community Survey suggested that non-Hispanic whites were 51.5% of Warren County's population.

25.80% of all households were made up of individuals, and 9.70% had someone living alone who was 65 years of age or older.

Warren County has the seventh highest per capita income in the state of Mississippi.

Warren County was historically Democratic until 1948, then was a Republican stronghold until 2008 (when it was narrowly carried by John McCain), and has recently become a bellwether.

The Board of Supervisors guides and establishes policies for the county government.

Members of the board of make decisions regarding economic development, public health and welfare and county roads.