Safra was born Vicky Sarfati (Βίκυ Σαρφάτη) in Greece,[4] the daughter of Fortunée (née Eskenazi) (1926–2015) and Alberto El Sarfaty (1914–2003).
[6] Her husband died in 2020 leaving his fortune to her and their children.
[3] She heads the Joseph Safra Philanthropic Foundation.
[3] She is a citizen of Greece but lives in Crans-Montana, Switzerland.
[7] As of December 2024, Forbes estimated her net worth at US$18 billion.