[10] She had her first acting experience when talent scouts from Public Television Service selected students from her school to serve as cast extras.

[10] In June 2024, Tseng graduated with a master's degree in communications management from Shih Hsin University, along with an outstanding achievement award, which she described as "[realising her] dreams".

[21][22] Tseng made her acting debut as a child actress at the age of 16, taking on her first role as a maid in The Legends of Tudigong [zh] without any dialogue.

[30][31] After starring in Amazing Strategist Liu Bo Wen, Tseng aimed to take on more sitcom roles to pursue a more stable income.

[20][9] In 2010, Tseng was cast in a recurring role as Tsin Mei-hsuan, a young woman suffering from domestic violence, in the drama series The Wife Wars [zh].

[32] That same year, she began to receive public attention for her role as Lin Ai-ting in the sitcom Lee's Family Reunion.

[37] In 2013, Tseng received her breakout role as Kuo Jia-jia, a selfish businesswoman who served as the main villain in the family drama Ordinary Love [zh].

[38] Her performance was critically acclaimed and earned her widespread recognition,[39] with TVBS describing the role as "iconic",[26] and several of the character's lines becoming popular memes.

[46] The following year, Tseng made a cameo as one of Tia Lee's character's split personalities in the thriller film The Perfect Girl.

[50] Tseng secured another main role as Miranda, a discipline teacher, in the coming-of-age drama series Youngsters On Fire [zh] from 2021 to 2022, appearing in all three seasons.