De la Fuente was born in Ríocaliente, and started his comics career in Adolfo López Rubio's studio in 1945.
In 1968 he started a collaboration with the French magazine Pilote, published by Dargaud, with the series Les diamants sanglants ("The bloody diamonds").
In 1969–1971, de la Fuente wrote and drawn the heroic fantasy series Haxtur for the Spanish magazine Trinca; in 1971 he also drew a single story for American publisher Warren, "I Am Dead, Egypt.
In 1979, he began the long western series Los gringos, written initially by Jean-Michel Charlier and, from 1992 onwards, by Guy Vidal.
[citation needed] His last works were a series of Tex Willer stories for Italian publisher Sergio Bonelli Editore and the French album Aliot, written by Alejandro Jodorowsky.