A principal in Victorine & Samuel Homsey, she was elected a Fellow of the American Institute of Architects (FAIA) in 1967,[1] the first woman architect from Delaware and only the eighth woman nationwide to achieve that honor.

She went on to receive her certificate in architecture in 1925 from the Cambridge School of Domestic and Landscape Architecture for Women (which was not yet a degree-granting institution); ten years later, after the school became affiliated with Smith College, she was awarded the M. Arch degree.

[3] After completing her studies at the Cambridge School in 1925, she worked as a drafter at the architectural firm of Allen & Collens in Boston (1926–27), and there she met Samuel Homsey, whom she married in 1929.

[5] They were perhaps the first Delaware architects to work in the International Style, and one of their early house designs was chosen by the Museum of Modern Art to represent the International Style in a 1938 Paris exhibition.

[4][7] In 1950, one of their house designs for small sites was included in a "Five-Star" series developed by Better Homes and Gardens, for which the working drawings and specifications could be purchased by mail for $5.